Abstract
This study included the synthesis of some new heterocyclic compounds starting with 5-aminotetrazole, which reacted with 2-hydroxy-4-methoxybenzaldehyde to get compound 1. Then, 1 was converted to a Schiff base (2) derivative by reacting 1 with 2-aminothiazole. Then, compound 2 was reacted with different compounds, namely alanine, 2-mercaptoacetic acid, 2-aminobenzoic acid, phthalic anhydride, and malic anhydride, leading to the heterocyclic products imidazolidine (3), thiazolidine (4), quinazoline (5), and oxazepane (6) derivatives, respectively. All these compounds are characterized by 13C-NMR, Fourier transform infrared spectroscopy, and 1HMNR. We also studied the biological activity of all heterocyclic derivatives toward two different kinds of bacteria and molecular docking studies.. KEYWORDS :Imidazolidine, Oxazepine, Quinazoline, Schiff bases, Thiazolidine.
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