Synthesis, Characterization, Biological Evaluation and Anti Corrosion Activity of Some Heterocyclic Compounds Oxazepine Derivatives from Schiff Bases

Hamak Kf,Eissa Hh

doi:10.4172/2161-0401.1000121

Abstract

A series of Schiff bases and their derivative (oxazepine) have been synthesized. 1, 4-Bis (3-aminopropyl)- piperazine was condensed with various aromatic aldehyde in ethanol in the presence of acetic acid as catalyst to yield the Schiff bases. These Schiff’s bases on treatment with phthalic anhydride gave substituted oxazepine. The structure of synthesized Schiff bases has been established on the basis of their spectral (FT-IR, Mass, 1H, 13C-NMR, elemental analysis) data. The purity of the compounds was confirmed by TLC. The biological activities of some prepared compounds were also studied against four different kinds of bacteria. These compounds were tested to determine their ability to inhibit corrosion of mild steel in 1 mol.l-1 H2SO4.

Highlights

The development of simple synthesis route to widely used organic compounds ring, using readily available reagents is one of the main objectives of organic synthesis
Nitrogen heterocyclic are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities, one–pot efficient synthesis of heterocyclic derivatives, may permit the development of novel therapies for the treatment of epilepsy, pain and other neurodegenerative disorder [1]
Oxazepine derivative was introduced in 1965 for use in relief of the psychoneuroses characterized by anxiety and tension; oxazepam is non-homologous seven member ring contain two hetero atoms [5]

Summary

Introduction

The development of simple synthesis route to widely used organic compounds ring, using readily available reagents is one of the main objectives of organic synthesis. Nitrogen heterocyclic are of a special interest because they constitute an important class of natural and non natural products, many of which exhibit useful biological activities, one–pot efficient synthesis of heterocyclic derivatives, may permit the development of novel therapies for the treatment of epilepsy, pain and other neurodegenerative disorder [1]. Some Schiff bases bearing aryl groups [2] or heterocyclic residues possess excellent biological activities [3], which has attracted many researchers’ attention in recent year. They have been reported to be used as analgesic, anthelmintic, antituberculer, plant growth regulator, antiviral, antifungal and anticancer [4]. Oxazepine compounds have medical and biological important and they have medicinal and pharmaceutical application. A send (as example) is an antidepressant with a mild sedative component to its action in animals (omoxazepine) reduced the uptake of noradrenalin and serotonin and block ed

Objectives

Methods

Conclusion