Synthesis and characterization of simple and binary drug delivery systems for sustainable release of ciprofloxacin

Abstract

Biopolymers are widely used for design sustained drug delivery systems (SDDS) and biomaterials for tissue engineering. Reducing wound infections still constitutes one of the major challenges facing the wound care. The aim of this study was to synthetize, characterize and evaluate a single (polymeric spheres) and a binary polymeric biomaterial (polymeric spheres imbedded in a poly(vinyl alcohol) (PVA) scaffold) as a SDDS. Polymeric spheres were prepared by complex coacervation and the binary system of the chitosan (CH) -PVA beads embedded in a PVA scaffold prepared by Ice Segregation Induced Self-Assembly (ISISA) process. Both systems were physicochemically characterized using Fourier Transform Infrared spectroscopy (FTIR), X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). In vitro ciprofloxacin (CFX) release kinetics were evaluated simulating physiological conditions under sink conditions. Physicochemical characterization showed interactions between all components forming beads; in contrast, beads-scaffold interactions were not detected making evident the presence of two different phases in the binary system. The CFX release kinetics revealed that both systems were SDDS, simple system release 97.0 ± 6.9% in 7 days, while the binary was 68.56 ± 6.6% during 14 days of evaluation. Binary system emerges as a potential tool for evaluate the long-lasting infection control in the treatment of skin wounds.