Abstract
Objectives: The major objective of this manuscript is to present synthesis and biomedical screening of some organic derivatives of bismuth having general formula (R3BiL2) by the method reported and characterized with the help of M.P., elemental, I.R., and NMR spectral analysis along with their antimicrobial and in vitro antitumor activity against human breast (MCF-7) and mammary cancer (EVSA-7) cell line.
 Methods: All the newly organobismuth having general formula [R3BiL2] were synthesised by the method reported especially using oxidative addition and complexation reactions.
 Results: It was found that organobismuth compounds have trigonal bipyramidal structure as per their elemental and spectral analysis and show potentiality as antimicrobial and antitumor agents.
 Conclusion: The newly synthesized organobismuth(V)substituted carboxylates were fully characterized chemically to ascertain their structure by sophisticated instrumental and spectral analysis resulted as trigonal bipyramidal structure. The compounds were also screened 1st time for antitumor and antimicrobial studies. The observations clearly indicated that organobismuth carboxylates show potent antimicrobial and antitumor activity.
Highlights
It is well reported that bismuth compounds have attracted considerable interest due to their biological and medicinal utility [1,2,3,4,5]. They have been utilized from more than 2 centuries in the treatment of gastrointestinal disorders such as dyspepsia, diarrhea, and peptic ulcer [6,7,8,9]. Bismuth salts such as colloidal bismuth sub-citrate, bismuth sub-salicylate, and ranitidine bismuth citrate are common agents used for Helicobacter pylori eradication therapy and promoted these compounds as antimicrobials [10,11]
The compounds were synthesized by the method reported earlier and characterized with the help of M.P., elemental, I.R., and NMR spectral analysis along with their antimicrobial studies, against different pathogenic bacterial and fungal strains and in vitro antitumor activity against human breast (MCF-7) and mammary cancer (EVSA-7) cell line and found that compounds have potentiality as antitumor and antimicrobial agents
The synthesis of tris(pentafluorophenyl)bismuth(III)dicarboxylates was performed in laboratory with the help of the following reactions: R Bi 3
Summary
It is well reported that bismuth compounds have attracted considerable interest due to their biological and medicinal utility [1,2,3,4,5] They have been utilized from more than 2 centuries in the treatment of gastrointestinal disorders such as dyspepsia, diarrhea, and peptic ulcer [6,7,8,9]. Bismuth salts such as colloidal bismuth sub-citrate, bismuth sub-salicylate, and ranitidine bismuth citrate are common agents used for Helicobacter pylori eradication therapy and promoted these compounds as antimicrobials [10,11]. The compounds were synthesized by the method reported earlier and characterized with the help of M.P., elemental, I.R., and NMR spectral analysis along with their antimicrobial studies, against different pathogenic bacterial and fungal strains and in vitro antitumor activity against human breast (MCF-7) and mammary cancer (EVSA-7) cell line and found that compounds have potentiality as antitumor and antimicrobial agents
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