Abstract
Objectives: The objectives of present manuscript are to synthesize some new organic derivatives of bismuth having general formula (RBiL2; wherein R = C6F5; L = Substituted aromatic carboxylic acid), and characterized with the help of M.P., elemental, I.R., and NMR spectral analysis to ascertain the structure of novel compounds. These compounds were also characterized for their in vitro antitumor activity against human breast (MCF-7) and mammary cancer (EVSA-7) cell line along with gastroprotective (anti-ulcer) activity in rats using standard methods.
 Methods: All the newly organobismuth having general formula (RBiL2) were synthesised by earliar reported methods especially using redistribution and complexation reactions. The in-vitro antitumor and gastroprotective studies were performed by using standard protocols and methods.
 Results: It was found that the compounds were crystalline solids, air stable, and soluble in common organic solvent, have sharp melting points, and possess trigonal/pyramidal structure, exhibit higher activity than the standard ranitidine when the tests were carried out with aspirin induced and moderate activity was seen when the tests were done with ethanol induced along with potential antitumor activity against MCF-7 and EVSA-7 cell lines.
 Conclusion: The newly synthesized organobismuth complexes were characterized to ascertain their structure by sophisticated instrumental and spectral analysis resulted as trigonal/pyramidal structure. The compounds were also screened 1st time for gastroprotective and antitumor activity in vitro. The observations clearly indicate that organobismuth carboxylates as reported here show potential gastroprotective and antitumor activity in vitro.
Highlights
It is seen in past few years that metal-based drugs have taken more attention of researchers due to their higher efficacy against different acute and pathogenic diseases in all over the world, especially in developing countries
It was found that these salts are useful for Helicobacter pylori eradication therapy, (H. pylori well known for the formation of gastrointestinal ulcer in human beings and organobismuth compounds are the only cure against this bacteria) and promoted for the microbial studies of various organobismuth compounds [8,9,10,11]
The organobismuth compounds were synthesized by earlier reported methods and all the solvents and reagents were purified and recrystallized before use
Summary
It is seen in past few years that metal-based drugs have taken more attention of researchers due to their higher efficacy against different acute and pathogenic diseases in all over the world, especially in developing countries. Organometallic drugs are recently used significantly in medical field for the treatment of precarious diseases such as tumor and cancer along with the treatment of malaria, syphilis, severe burns, leishmaniasis, trypanosomiasis, manic depressive psychosis, rheumatoid arthritis etc. It was found that these salts are useful for Helicobacter pylori eradication therapy, (H. pylori well known for the formation of gastrointestinal ulcer in human beings and organobismuth compounds are the only cure against this bacteria) and promoted for the microbial studies of various organobismuth compounds [8,9,10,11]. The present manuscript deals the antitumor and gastroprotective studies of novel organobismuthanes in +3 oxidation states which are screen 1st time for biomedicinal perspectives
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