Abstract
A modified straightforward process is introduced to synthesize zinc oxide nanoparticles into the pores of a mesoporous silica SBA-16 as host. The mesoporous structure and the ZnO nanoparticles were analyzed by infrared spectroscopy, X-ray diffractometry, scanning electron microscopy, transmission electron microscopy, and nitrogen sorption analysis. The loading and release of temozolomide from ZnO/SBA-16 nanocomposite were studied. Encapsulation loading efficiency % was surveyed by design of experiment software and the features of release were measured. Results show the highest percentage of adsorption can be achieved by optimization of the effective factors on loading drug. Moreover, SBA-16 loaded with nano ZnO exhibited controlled drug release.
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