Synthesis and characterization of indolizine and 5,6-benzo-fused indolizine derivatives with their pharmacological applications

Abstract

A efficient synthesis of novel Indolizine and 5,6-benzo-fusedindolizine derivatives are achieved by using substituted pyridine and substituted quinoline with electron-deficient acetylene and phenacyl bromides in presence of TEA base with acetonitrile solvent. The structures of newly synthesized compounds have been confirmed by spectroscopic techniques like 1H-NMR, 13C-NMR, LC-MS, IR and Elemental analysis. All the synthesized compounds were studied their lipid peroxidation activity. Synthesized compounds showed mild to moderate lipid peroxidase inhibitory activity. Compound 1a to 1e showed moderate activity and 1f, 2a and 2d showed minimal activity compared to ascorbic acid.