Abstract
A new library of chalcone functionality bearing benzothiazol-oxazole-pyrazine (10a-j) derivatives were designed, synthesized and screened for their anticancer activity against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay. The results were compared with the etoposide used as a positive control. Most of the tested compounds displayed good to moderate activity compared to etoposide. Among them, compound 10j showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines with IC50 values of 0.01 ± 0.0073 µM, 0.03 ± 0.0087 µM, 0.06 ± 0.0066 µM, and 0.13 ± 0.055 µM respectively
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