Abstract
An efficient synthesis of novel ethyl 7-amino-3-benzoylindolizine-1-carboxylate derivatives has been described using 4-aminopyridine and different phenacyl bromides in acetone and fallowed by reacting with electron-deficient acetylenes in the presence of potassium carbonate base with anhydrous DMF solvent. The structures of newly synthesized compounds have been confirmed by spectroscopic techniques and studied there in vitro antioxidant properties using a DPPH scavenging method. The compound ethyl 7-amino-3-(4-methoxybenzoyl) indolizine-1-carboxylate has shown good antioxidant potent. The compound ethyl 7-amino-3-(4-methoxybenzoyl)indolizine-1-carboxylate, ethyl 7-amino-3-(4-bromobenzoyl)indolizine-1-carboxylate and ethyl 7-amino-3-(4-chlorobenzoyl)indolizine-1-carboxylate has very potent to anti-bacterial activity.
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