Synthesis and antibacterial activity of the cyclic 2-substituted thyenopyrimidin-4-ones by bubbling with hydrochloric gas of cycloalkane[<i>b</i>]-2-(<i>n</i>-acylamino)-3-cyanothiophenes

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The reaction of acylation of some 2-amino-3-cyanocycloalkane[ b ]thiophenes with chlorides of various carboxylic acids gave the corresponding cycloalkane[ b ]-2-( N -acylamino)-3-cyanothiophenes, bubbling with hydrochloric gas from an alcoholic solution of amidonitriles to obtain cyclic 2-substituted thienopyrimidin-4-ones. The study of the antibacterial activity of the compounds against gram-positive and gram-negative microorganisms showed that most of them exhibit a weak antibacterial effect against staphylococci.