Abstract
The hydroxyl end groups of Tetronic T1107 were modified with chloroacetylchloride. The chloroacetylated Tetronic T1107 was then modified tointroduce amino group in the side chain by reacting it with ethylenediamine.New Schiff bases were synthesized by the reaction of aminated Tetronic1107 with different aromatic aldehydes such as p-hydroxybenzaldehyde,vanillin, p-chlorobenzaldehyde, and p-dimethylamino benzaldehyde. Thechemical structure of the obtained Schiff bases was confirmed by FT-IR and1H-NMR spectroscopy. The antibacterial activity of Schiff base compoundswas investigated by well diffusion method against gram-negative bacteria(Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris) and grampositivebacteria (Staphylococcus aureus). The results showed that thepolymeric Schiff base compounds have a significant inhibiting effect on allthe tested microorganisms. It was also found that the antibacterial activity ofthe Schiff base was higher than that of unmodified tetronic 1107.
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