Abstract
This study including synthesis of some new Schiff bases compounds [1‐6] from the reaction of Sulfamethoxazole drug with some aromatic aldehydes in classical Schiff base method then treatment Schiff bases with succinic anhydride to get oxazepines rings [7-11]These derivatives were characterized by melting point, FT‐IR, 1H NMR and mass spectra. Some of synthesized compounds were evaluated in vitro for their antibacterial activities against three kinds of pathogenic strains Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by agar diffusion disk method, and against the fungal species (Candida). The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.
Highlights
Iraqi Journal of Market Research and Consumer Protection أكساصبٍٍ انًشخقت يٍ دٔاء-1,3ٔ ححضٍش حشخٍض ٔدساست انفعانٍت انبإٌنٕجٍت نبعض يشكباث قٕاعذ شف انسهفايٍزاكساصٔل
This study including synthesis of some new Schiff bases compounds [1‐6] from the reaction of Sulfamethoxazole drug with some aromatic aldehydes in classical Schiff base method treatment Schiff bases with succinic anhydride to get oxazepines rings [711]These derivatives were characterized by melting point,FT‐IR,1H NMR and mass spectra
The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug
Summary
أكساصبٍٍ انًشخقت يٍ دٔاء-1,3ٔ ححضٍش حشخٍض ٔدساست انفعانٍت انبإٌنٕجٍت نبعض يشكباث قٕاعذ شف انسهفايٍزاكساصٔل. INTRODUCTION 4-Amino-N-5-methyl-3-isoxazolylbenzenesulfonamide is the common name of Sulfamethoxazole, but N1-5-Methyl-3-isoxazolyl sulfanilamide, is the IUPAC name(Figure 1).This drug was considered by previous working groups (Lyon, 1980; Lyon, 1987).Sulfamethoxazole is an antibiotic that has been used since the 1990s to treat various general injuries in humans and different species. Pattern of tissue delivery, antibacterial medication that is widely used to treat various systemic infections worldwide with trimethoprim or pyrimethamine. Researches on complexes of sulfamethoxazole have a lot of physiological and pharmacological due to complexes of sulfa drugs have been discovered to be more bacteriostatic than the medication themselves(Alias et al, 2015; Al-Khodir, 2015)
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