Abstract
In this study, we report the synthesis of some new Schiff base compounds (1-5) from the reaction of amoxicillin with some aromatic aldehydes in classical Schiff base method. These derivatives were characterized by melting point, elemental analysis, FT-IR and 1 H NMR data. All the synthesized compounds were evaluated in vitro for their antibacterial activities against two Gram positive ( Staphylococcus aureus, Streptococcus faecalis ) and two Gram negative ( Escherichia coli, Pseudomonas aeruginosa ) microorganisms in different concentrations (10 -1 , 10 -3 , 10 -5 and 10 -7 M) by agar diffusion disk method. The results showed that some of these derivatives have good antibacterial activities compared to biological activity of parent drug.
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