Abstract
Syntheses of new polysubstitued dihydrofurans mediated by manganese(III) acetate
Highlights
Dihydrofurans are an important scaffold that occupies a prominent place in the organic syntheses, as they are present in biologically active synthetic molecules and in a wide variety of naturally occurring compounds [1,2]
Their syntheses by the radical cyclization reaction of active methylene compounds with unsaturated systems via transmetal salts (Mn3+, Ce4+, Cu2+) is one of the best method [3-14]
Our research group was interested in preparing of dihydrofurans by manganese(III) acetate have shown antifungal and antibacterial activity [15,16] (Fig. 1)
Summary
Dihydrofurans are an important scaffold that occupies a prominent place in the organic syntheses, as they are present in biologically active synthetic molecules and in a wide variety of naturally occurring compounds [1,2]. Their syntheses by the radical cyclization reaction of active methylene compounds with unsaturated systems via transmetal salts (Mn3+, Ce4+, Cu2+) is one of the best method [3-14]. We would like to report a biologically interesting dihydrofurans (3a and 3b) by the mediated of Mn(III) acetate in moderate yields For this purpose, 3-oxo-3(thiophen-2-yl)propanenitrile (1a) and 3-oxo-3-phenylpropanenitrile (1b) were used as active methylene compounds and 3-methylbut-2-en-1-ol (2a) were used as an unsaturated alcohol
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