SYNTHESES AND CRYSTAL STRUCTURES OF COPPER(II) AND ZINC(II) COMPLEXES DERIVED FROM 5-BROMO-2-((CYCLOPROPYLIMINO)METHYL)PHENOL WITH ANTIBACTERIAL ACTIVITY

Abstract

Four new complexes of copper(II) and zinc(II), [Cu2L4] (1), [Cu2L2(N(CN)2)2]n (2), [Zn(HL)2I2] (3) and [Zn(HL)2(NCS)2] (4), where L is 5-bromo-2-((cyclopropylimino)methyl)phenolate, HL is the zwitterionic form of 5-bromo-2-((cyclopropylimino)methyl)phenol, were synthesized and characterized by elemental analysis and IR and UV-Vis spectroscopy. Structures of the complexes were further confirmed by single crystal X-ray structure determination. Complex 1 is a phenolate bridged dinuclear copper(II) compound, with the Cu atom in square pyramidal coordination. Complex 2 is a phenolate and dicyanamide bridged polynuclear copper(II) compound, with the Cu atom in square pyramidal coordination. Complexes 3 and 4 are mononuclear zinc(II) compounds, with the Zn atoms in tetrahedral coordination. The compounds were assayed for their antimicrobial activities. Complexes 1 and 2 have the most activities on B. subtilis, with MIC values of 1.2 μg mL–1.