Synergistic Nootropic Activity of Ethanolic Leaf Extracts of Ziziphus Jujuba and Tinospora Cordifolia against Stress Induced Rats

Abstract

Aim: The present investigation deals with the preliminary phytochemical analysis, synergistic nootropic activity of ethanolic leaf extracts of Ziziphus jujuba and Tinospora cordifolia against stress induced rats.
 Methods: Nootropic activity was observed in Albino Wistar rats of either sex using behavior paradigms such as elevated plus maze, staircase and morris water maze.
 Results: In elevated plus maze and morris water maze, the rats were treated with extracts at doses (100 and 200 mg/kg-po) for 9 days and were observed on 9th day of treatment. Piracetam (100 mg/kg) was used as standard drug for comparison. In the elevated plus maze, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the transfer latency when compared to 100 mg/kg. In the staircase, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the number of climbings and the number of rearings when compared to 100 mg/kg. In the morris water maze, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the escape latency when compared to 100 mg/kg and control.
 Conclusion: The combination of these two medicinal plants Ziziphus jujuba and Tinospora cordifolia possessed significant synergistic nootropic activity and further research attempts can be made so as to isolate the novel moiety molecules which can be elucidated and can be evaluated for their therapeutic potential.