Abstract
Sympathetic overdrive (sympathetic hyperactivation) plays a key role in the pathogenesis of coronary heart disease and its adverse outcomes. An increased heart rate at rest as a manifestation of hyperactivation of the sympathetic nervous system is a factor worsening the prognosis in patients with ischemic heart disease.Beta-blockers are recognized as first-line drugs for controlling symptoms in coronary heart disease with a proven effect on prognosis. Bisoprolol is a β1-selective beta-blocker with high antianginal and prognostic modulating efficacy.
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