SWELLING OF THE SUBCUTANEOUS INTERSTITIUM UNDER THE INFLUENCE OF ISONIAZID AND DIFFERENT PH LEVELS

Abstract

The article deals with the issues of interstitial conductivity for isoniazid and saline solution with different pH levels. Experimental studies were conducted to substantiate and explain the mechanisms of effectiveness of indirect endolymphatic drug administration. At the present stage, lymphotropic administration of anti-tuberculosis drugs occupies a worthy place in the complex therapy of patients with pulmonary and extrapulmonary tuberculosis. Lymphotropic therapy is an etio-pathogenetic method of treating patients and consists of regional subcutaneous injections of medicinal solutions with the use of lymphotropy factors, among which it is important to create an active functioning of the interstitial zones of lymphotropic administration, which determines the flow of drugs into the lymphatic channel. The influence of acidification and alkalinization of the medium on the hydrophilicity of the interstitium of the subcutaneous tissue of the parasternal zone, armpit, and interdigital spaces was studied. As incubation solutions, saline solution with pH 6.9, pH 7.4, pH 6.0 and 10% isoniazid solution (10%H) were used. It was found that the interstitial subcutaneous tissue of the lymphotropic injection zones is characterized by different intensity of swelling, which is probably due to the morphological features of the fiber, different content of loose connective and adipose tissues in it. The swelling coefficient is regulated by the pH level of incubation solutions and the chemical structure of the administered lymphotropically medicinal substance. Features of interaction between interstitial lymphotropic points and the drug should be taken into account when prescribing indirect endolymphatic therapy schemes. It is likely that the pH of the administered solutions must be maintained at the level of the physiological norm (7.4). Isoniazid in the lymphotropic points creates a depot that is more pronounced in the parasternal region.