Abstract
Sustained release drug delivery system is designed to sustain the release of the drug dosage forms at a predetermined rate. Sustained release formulation maintains uniform drug level in therapeutic window, improved efficacy of drug by localization at the site of action with better patient compliance, reducing the dose required, providing uniform drug delivery. The sustained release formulations minimize the frequency of drug administration and do not interfere with the therapeutic action of the drug. The use of sustained release matrix technology for antibiotics is effective in preventing the resistant of antibiotics in body on irrational use. Drug release through matrix SRDDS is determined by Polymer swelling, Water penetration, Drug dissolution, diffusion, Matrix erosion. The present article contains brief review on various formulation approaches for Sustained release drug delivery system, advantages, selection criteria for matrix SRDDS and use of cefixime trihydrate in formulating matrix SRDDS.
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