Sustainable metal-organic frameworks (MOFs) for drug delivery systems

Abstract

Metal-organic frameworks (MOFs) have emerged as a promising class of materials for drug delivery applications due to their tunable properties, high surface area, and porous nature. However, the long-term sustainability of MOFs in drug delivery applications remains a major challenge. The degradation of MOFs can result in the release of toxic metal ions, compromising their biocompatibility and safety. To overcome this challenge, sustainable MOFs for drug delivery have been developed by incorporating biodegradable linkers and metal ions that are less toxic. These sustainable MOFs have shown promising results in drug delivery applications, exhibiting excellent biocompatibility and controlled release of drugs. In this perspective article, I discuss the current state-of-the-art sustainable MOFs for drug delivery systems. I provide an overview of the design strategies for developing sustainable MOFs, including the use of biodegradable linkers, non-toxic metal ions, and hybrid MOFs. I also highlight the challenges and opportunities in developing sustainable MOFs for drug delivery applications. Furthermore, I discuss the potential of sustainable MOFs for targeted drug delivery, which has significant implications for improving the efficacy and reducing the toxicity of drugs. Also, I emphasize the importance of considering the sustainability of MOFs in drug delivery applications and the need for further research in this area.