Metal organic frameworks: an effective application in drug delivery systems

Abstract

Metal organic frameworks (MOFs) are networks constructed from metal ions or clusters and multi-dentate organic linkers with coordinate bonds. They are porous and crystalline and have one, two or three directional structures. The MOFs have found varied applications in a variety of fields like catalysis, energy storage, gas purification and separation, super-capacitors to name a few. This review gives a general overview into the different methods used for the synthesis of MOFs, their structure and characteristics, also highlighting its application in drug delivery. The properties like targeted and stimulus-based delivery, nontoxic effects, multi drug loading capacity and sustained release have enhanced the use of MOFs in drug delivery. Drugs required for chronic diseases, which necessitate specific organ treatment, can be delivered to the particular site in the body by using MOFs. This paper also describes some of the ailments like pulmonary diseases, arthritis and HIV which can be treated by targeted drug delivery, using MOFs.