Abstract
Objective To analyze the prognostic factors for patients with hepatic encephalopathy(HE)in acute -on-chronic liver failure(ACLF). Methods A retrospective analysis was performed on 159 ACLF patients with HE. The hepatic encephalopathy was determined to baseline, the patients were divided into survivors(n=13)and nonsurvivors(n=146), The 32 factors affecting the prognosis were analyzed by Cox proportional hazard model with SPSS. Results One-month, three-month,and six-month survival rates were 20.13%,10.06%and 8.18%, respectively. Cox regression analysis of prognostic factors showed that it could the stage of hepatic encephalopathy and HRS significantly improve the survival rate of the patients with HE in acute-on-chronic liver failure. The stage of hepatic encephalopathy and HRS could significantly decrease the survival rate of the patients(χ2=18.344,11.368,all P<0.05),elevated the levels of hepatic encephalopathy(relative risk(RR)=1.591)and HRS(RR=1.809)indicate worse prognosis with hepatic encephalopathy in acute-on-chronic failure. Conclusion The stage of hepatic encephalopathy and HRS were independent risk factor sof prognosis in acute-on-chronic liver failure. Key words: Liver failure; Hepatic encephalopathy; Factor analysis, statistical
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