Abstract
1. 1. Diethylstilbestrol (DES) at a dosage of 25 μg. per mouse stimulated the reticuloendothelial system (RES) without inducing RE organ hypertrophy. Associated with the increased phagocytic activity was a decreased Plasmodium berghei NYU-2 parasitaemia and an enhanced mean survival time. 2. 2. The trisaccharide melezitose (1 mg. per mouse) similarly stimulated the RES without inducing any RE organ hypertrophy, and decreased the P. berghei parasitaemia and enhanced the mean survival time. 3. 3. The enhanced phagocytic activity in the diethylstilbestrol- and melezitose-treated mice was specifically attributed to an increased Kupffer cell phagocytosis.
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