Sulfamic acid catalyzed grinding: A facile one-pot approach for the synthesis of polysubstituted pyrazoles under green conditions

Abstract

A competent, rapid and simple grinding procedure for the synthesis of pharmacologically relevant polysubstituted pyrazoles catalyzed by sulfamic acid is reported via multicomponent reaction of substituted arylaldehydes, 4-nitrophenylacetonitrile, hydrazine hydrate, ethyl acetoacetate under solvent-free reaction conditions. In our reported protocol, four different reactants featuring diverse functional groups are assembled in one pot, enabling the synthesis of more diverse molecular structures in a facile manner.