Abstract
Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with DV, particularly DV serotype 2 (DV2). HepG2 cells were grown in various culture milieu. Total cellular RNA and proteins were extracted and quantified. Results demonstrated sequestration of immunoproteasome subunits LMP2 and LMP7 in DV2-infected cells. This study provides insights into the mechanisms underlying immune evasion by DV.
Highlights
Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by major histocompatibility complex (MHC) class I molecules
This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with DV, DV serotype 2 (DV2)
The present study aimed to investigate the effects of DV2 infection on low molecular weight polypeptide-2 (LMP2) and low molecular weight polypeptide-7 (LMP7) expression in human HepG2 cells using YK73, which has been shown to act as an antiviral agent against DV5
Summary
Abstract: Introduction: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with DV, DV serotype 2 (DV2). Results: Results demonstrated sequestration of immunoproteasome subunits LMP2 and LMP7 in DV2-infected cells.
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