Abstract
Dengue virus (DENV) evolution has had a significant impact on disease pathogenesis, virulence, and epidemiology in Mexico. Novel genotypic variation in DENV serotypes and genotypes may influence the magnitude and severity of dengue epidemics, as evidenced by 2009 data from Veracruz State. The data presented herein is related to the publication entitled “Epidemiological Implications of the Genetic Diversification of Dengue Virus (DENV) Serotypes and Genotypes in Mexico” [1]. Raw data and trees provide epidemiological data on DENV prevalence and a comprehensive phylogeny of both representative sequences collected from an NCBI repository, and 28 additional isolates from acute-phase plasma samples diagnosed with dengue fever or severe dengue (Raw sequencing data is hosted in the public repository Mendeley Data (http://dx.doi.org/10.17632/bf2kdhhf6x.2). Phylogenetic trees for each DENV serotype (DENV-1, -2, -3 and -4) were constructed using these sequences by a maximum likelihood methodology as well as a Bayesian Markov chain Monte Carlo (MCMC) integration approach. Phylogenetic trees exhibited: (1) DENV-1, genotype V, (2) the DENV-2 Asian/American and Asian II genotypes, (3) DENV-3, genotype III, and (4) DENV-4, genotype I. This data can be beneficial for future analyses on DENV serotype and genotype structure and the introduction of novel DENV genotype sequences in the Americas, for the further elucidation of dengue etiology.
Highlights
Authors Eduardo Dominguez-de-la-Cruz, María de Lourdes Muñoz, Ericel Hernández-García, Gerardo PérezRamírez, Randy E
This data will serve as a reference for future analyses on the incidence, epidemiology, and introduction of novel dengue virus (DENV) genotypes/serotypes in Mexico—fostering a greater understanding of the emergence of variable dengue strains in the Americas
Novel DENV sequence data from Mexico can aid the future phylogenetic classification of dengue serotypes and genotypes circulating in the Americas, useful to understanding virus evolution and the association between genotype/serotype and disease pathogenesis
Summary
This data will serve as a reference for future analyses on the incidence, epidemiology, and introduction of novel DENV genotypes/serotypes in Mexico—fostering a greater understanding of the emergence of variable dengue strains in the Americas. All institutions involved in public health, disaster relief, and arbovirus control programs can benefit from this data through a more nuanced understanding of the association between specific genotypes (within serotypes) and presentation of disease. Novel DENV sequence data from Mexico can aid the future phylogenetic classification of dengue serotypes and genotypes circulating in the Americas, useful to understanding virus evolution and the association between genotype/serotype and disease pathogenesis. DNA sequencing and serotype identification of DENV samples in Veracruz State and elsewhere in Mexico can provide crucial supporting data for future control programs, reemergence research, source/sink studies, transnational transmission pattern analysis, and herd immunity research. The epidemiological analysis of dengue virus in Veracruz State in 2009 can provide a foundation for further insight into the interrelationship between climatological factors, viral evolution, and disease distribution
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