SUBMICROSCOPIC CHANGES OF RAT’S CEREBRAL CORTEX IN TERMS OF DMG-INDUCED EXPERIMENTAL ONCOGENESIS AND UNDER CONDITIONS OF NANOMATERIALS APPLICATION

Abstract

Abstract. Expansion and enhancement of research on colorectal cancer, particularly its impact on the cerebral cortex, stand as a profoundly critical task for the scientifi c community.The objective of this study was to identify submicroscopic alterations occurring in the brain cortex during the development of experimental colorectal cancer. Additionally, the article examines the potential application of nanoparticles in the context of colorectal cancer treatment. Animals were divided into three groups: Group I consisted of 35 intact animals, Group II had 70 animals with DMH-induced carcinogenesis, and Group III included 20 animals with neoplastic lesions receiving a composition of Au/Ag/Fe nanoparticles. Experimental carcinogenesis was induced using N, N-dimethylhydrazine hydrochloride, administered once a week for 30 weeks. Animals in Group III were given an intra- gastric dispersion of Au/Ag/Fe nanoparticles once daily for 21 days. Histological preparations were made using conventional methods. Examination of the specimens was conducted using the PEM-125K electron microscope.Results. The utilization of Au/Ag/Fe nanoparticles facilitated the restoration of structural elements within the cerebral cortex at a submicroscopic level compared to animals subjected to DMH-induced carcinogenesis. The application of nanoparticle composition contributed to the restoration of structural elements in the cerebral hemisphere, reduction in alternative changes in neurocytes, and regeneration of damaged blood capillaries in the organ.Conclusion. Drawn from the study’s outcomes indicate the eff ectiveness of applying Au/Ag/Fe nanoparticles in mitigating the adverse eff ects of the development and progression of DMH-induced adenocarcinoma in situ on the cerebral cortex.