Morphological changes in the cerebral cortex under conditions of DMH-induced colon adenocarcinoma and the corrective effect of the Au/Ag/Fe nanoparticle composition

Abstract

This article investigates the corrective influence of the composition of Au/Ag/Fe nanoparticles on the morphology in the cerebral cortex under the conditions of DMG-induced adenocarcinoma in situ.Objective of the study was to explore the potential use of metal nanoparticle composition to correct morphological disturbances in the cerebral cortex under the conditions of DMH-induced neoplastic lesions of the colon.Material and methods. The study involved 105 sexually mature male white rats. All animals were divided into three groups: group I - 35 intact animals, group II - 70 animals with DMG-induced adenocarcinoma, group III - 20 animals with a simulated adenocarcinoma of the colon to which the Au/Ag/Fe nanoparticle composition was administered. Experimental carcinogenesis was induced by weekly administration of N,N-dimethylhydrazine hydrochloride over 30 weeks. Animals with DMG-induced carcinogenesis were treated with an intragastric administration of an aqueous dispersion of Au/Ag/Fe nanoparticles once a day for 21 days. Histological specimens were prepared following widely accepted methods. A MICROmed SEO SCAN light microscope and a Vision CCD Camera were used for studying and photodocumenting the specimens. Results. The application of Au/Ag/Fe nanoparticles led to the regeneration of structural elements in the cerebral cortex compared to the group of animals with DMG-induced carcinogenesis. The corrective effect of the nanoparticle composition was characterized by the restoration of structural elements in the cerebral hemispheres, a reduction in pathological changes in neurons, and the regeneration of damaged blood vessels in the organ. Conclusions. The obtained results indicate the effectiveness of Au/Ag/Fe nanoparticles in reducing the consequences of the development and progression of DMG-induced adenocarcinoma in situ in the cerebral cortex.