Submembranous cytoskeleton and neuroplasticity in hypothalamo-neurohypophysial system of rats and mice

Abstract

Event Abstract Back to Event Submembranous cytoskeleton and neuroplasticity in hypothalamo-neurohypophysial system of rats and mice Roza Benabdesselam1, Ouahiba Benmessaoud2 and Latifa Dorbani-Mamine2* 1 University M. Mammeri, ISB, Algeria 2 University of Sciences and Technologies H. Boumediene, Neurochemistry group, Loboratory of Biology and Physiology of Organisms, Faculty of Biology, Algeria The regulation of water in the body is vital. It occurs due to the sensation of thirst, which itself is caused by intra- and extracellular dehydration. The baroreceptors and peripheral and central voloreceptors detect modifications of blood hyperosmolarity and hypovolemia and communicate with osmosensitive nerve centers that send efferents to magnocellular neurons. These hypothalamic neurons produce and secrete antidiuretic hormone, arginine vasopressin (AVp) and oxytocin (Ox) hormones. Secretion occurs by exocytosis of dense core granules in the neurohypophysial capillary surrounding space and then in the general circulation. The magnocellular neurons are closely associated with glial cells such as pituicytes in neural lobe and tanicytes in median eminence. The molecular processes that generate and regulate secretion are based mainly on the submembranous and cytoplasmic cytoskeletal and membranous domains components. For the first time, we describe the distribution of dystrophins (Dp), utrophins (Up) and their associated proteins (dystrophin-associated proteins, DAPs) distribution in glial, neuronal and vascular endothelial cells of hypothalamo-neurohypophysial system. Dystrophins are the products of the gene altered in Duchenne muscular dystrophy, a debilitating lethal disease. The utrophins are autosomal gene products homologous to dystrophins. These two family proteins have binding capacities even to cytoplasmic and membranous DAPs forming a molecular bridge between the intracellular environment by binding to actin filaments and the extracellular space through their interaction with extracellular matrix components. Previous and present results obtained by immunohistochemistry, Western blotting and in situ hybridization approaches using rats, Dp71 knock out mice and their wild type have identified, in part, the molecular composition of these complexes in rat and mice hypothalamo-neurohypophysial systems compared to that of muscle, used as a reference. Otherwise, the distribution of these complexes is modified under dehydration conditions and suggests different roles as in receiving signals, by implication in the receptor clustering, in granules secretion. All these roles are accompanied with plasticity modifications, either of neurons or of glial cells. Acknowledgment: We thank Professor D. Mornet, University of Montpellier (France) for the donation of antibodies, and Drs A. Rendon and Professor H. Hardin-Pouzet, University Paris (France) Conference: 2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010. Presentation Type: Oral Presentation Topic: Oral Session 3: The plastic brain: implications for learning and education Citation: Benabdesselam R, Benmessaoud O and Dorbani-Mamine L (2010). Submembranous cytoskeleton and neuroplasticity in hypothalamo-neurohypophysial system of rats and mice. Front. Neurosci. Conference Abstract: 2nd NEUROMED Workshop. doi: 10.3389/conf.fnins.2010.12.00029 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Jun 2010; Published Online: 04 Jun 2010. * Correspondence: Latifa Dorbani-Mamine, University of Sciences and Technologies H. Boumediene, Neurochemistry group, Loboratory of Biology and Physiology of Organisms, Faculty of Biology, Algiers, Algeria, latifa.dorbani@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Roza Benabdesselam Ouahiba Benmessaoud Latifa Dorbani-Mamine Google Roza Benabdesselam Ouahiba Benmessaoud Latifa Dorbani-Mamine Google Scholar Roza Benabdesselam Ouahiba Benmessaoud Latifa Dorbani-Mamine PubMed Roza Benabdesselam Ouahiba Benmessaoud Latifa Dorbani-Mamine Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.