Subchronic toxicity of huanghuali tea in rats

Abstract

Objective To assess subchronic toxicity of huanghuali ( Dalbergia odorifera T. Chen ) tea in rats. Methods A ninety-day feeding experiment was performed in 140 specific pathogen free Sprague-Dawley (SD) rats according to the Food Safety Toxicology Evaluation Procedures and Methods – 2015 Edition. Results During the experiment, all the rats were generally in good condition and no death was observed. Compared with those of the control rats, there was no significant difference in weekly body weight, food intake and food utilization rate of final phase, hematology and serum biochemical indexes, organ weight and organ/body weight ratio in rats of all the dose groups ( P > 0.05). No remarkable changes were observed in urinary routine indicators, eye examination and gross anatomy, and histopathological examinations. Conclusion Huanghuali tea shows no obvious toxicity, with a no observed adverse effect level (NOAEL) of 22.22 g/kg·bw, in rats. 【摘 要】 目的 探讨黄花梨茶对大鼠的亚慢性毒性作用。 方法 参照 2015 版《食品安全性毒理学评价程序和方法》中的 90 d 喂养试验方法对黄花梨茶的亚慢性毒性进行分析。 结果 试验观察期间大鼠一般状态良好，无死亡；与对照组比较，各剂量黄花梨茶组大鼠体重、进食量和食物利用率、动物血液学和血清生化指标以及脏器重量及脏器/体重比值无明显变化，差异均无统计学意义（ P > 0.05）；尿常规指标、眼部检查及大体解剖和组织病理检查未见明显与受试物有关的异常改变。 结论 黄花梨茶对大鼠无明显亚慢性毒性作用，最大未观察到有害作用剂量（NOAEL）为 22.22 g/kg。