Abstract
The PRESERFLO MicroShunt (MicroShunt) is a novel glaucoma device to treat glaucoma. It is made from poly(styrene-block-isobutylene-block-styrene) (SIBS), which was the first elastomer developed primarily for long-term implant applications with the intention of minimizing the foreign body reaction. SIBS differs from conventional organic polymers in that it is composed of only carbon and hydrogen atoms without any heteroatoms, which play a role in the foreign body reaction. Furthermore, there are no cleavable groups on its backbone or side groups, and its nonsaturable backbone prevents the occurrence of embrittlement and cracking over time. Early work in pigs and rabbits confirmed its biocompatibility. SIBS has been used in the heart in over six million patients since 2000 and has been used in tens of thousands of eyes as a glaucoma shunt since 2006. This subchapter reviews the chemistry of SIBS, the design of the MicroShunt, and published safety and efficacy data from clinical studies.
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