Study the effects of CBP treatment on serum resistin in patients with SIRS

Abstract

Objective To study the effects of CBP treatment on serum resistin in patients with SIRS. Methods 120 patients with SIRS were randomly divided into conventional treatment group(60 cases)and CBP group(60 cases). CBP group were treated with continuous blood purification for 72 hours besides conventional treatment. Serum levels of resistin was determined with ELISA dynamically before treatment and 24,48,72and 96 hours after the treatment. The APACHE Ⅱ score was evaluated at the same time. Results The level of ser-um resistin in patients in two SIRS groups was significantly higher than control group( P 0. 05 ), after 96 hours of treatment, Patients in each group were significantly lower serum resistin. To lower serum resistin levels slow in the conventional treatment group ( P < 0. 05 ), and the gradual lowering of serum resistin levels in the CBP group ,48 hours after treatment was significantly lower than before treatment ( P < 0. 05 ), 72 hours after treatment to reduce even more pronounced( P < 0. 01 ). There was positive correlation between resis- tin and APACHE Ⅱ scores( r = 0. 68, P < 0. 01 ). Condusion CBP treatment could reduce the role of resistin which is a inflammatory factor in the blood, improve the function of endothelial ceils in patients, and treatment provides a now monitoring indicators for observation of CBP. Key words: Continuous blood purification (CBP); Systemic inflammatory reactive syndrome(SIRS) ; Resistin