Abstract
Abstract Introduction: Diabetes is a group of metabolic diseases characterized by hyperglycemia due to insulin secretion or action defects. Gastrointestinal neuropathies in patients with diabetes represent vital aspects of the chronic course of the disease. This can be perceived as chronic delayed gastric emptying associated with nausea, vomiting, postprandial fullness, weight loss, anorexia, and abdominal pain without evidence of mechanical obstruction. Traditional treatments for diabetic gastroparesis include dietary changes and medication, but severe cases may require surgery or gastric electrical stimulation. Pistacia species extracts suggest alleviating gastrointestinal symptoms, yet no Indian studies support the evidence despite Pistachia plant species being present in the Great Himalayan regions. This study explores the therapeutic potential of Pistacia plants in treating diabetic gastroparesis, leveraging their natural antioxidants to enhance gut motility. Materials and Methods: This randomized controlled trial will be conducted in two regions of Uttarakhand, India: Garhwal (7 centers) and Kumaon (8 centers) over a total of 15 centers. Each center will enroll 10 patients with diabetic gastroparesis who consent to participate based on a predefined Gastroparesis Cardinal Symptom Index (GCSI) score, totaling 150 patients using convenience sampling. Patients with GCSI scores ≥15 will receive twice-daily drug therapy for 10 days, overseen by a designated study observer at each center. Data will be collated at AIIMS Rishikesh for analysis. Discussion: This study aims to validate the effectiveness of Pistacia lentiscus plant extract in treating diabetic gastroparesis, addressing a critical gap in Indian literature. If successful, P. lentiscus could offer a cost-effective and minimally invasive intervention for severe gastroparesis in India. Conclusion: The study’s robust design and methodology inspire confidence in its potential contribution to diabetes management.
Published Version
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