Study on the effect of magnesium sulfate combined with labetalol on pregnancy-induced hypertension syndrome and its effect on calcium and magnesium levels in pregnant women's plasma and erythrocytes

Abstract

Objective To analyze the efficacy of magnesium sulfate combined with labetalol on pregnancy induced hypertension (PIH) and its effect on the intracellular calcium and magnesium levels in pregnant women's plasma and erythrocytes. Methods Ninety-four patients with PIH admitted from February 2016 to February 2018 in hospital were divided into study group (47 cases) and control group (47 cases) according to different treatment methods. Both groups were treated with labetalol. The study group was treated with magnesium sulfate on the basis of this treatment. Then the treatment effects of the two groups were analyzed. Results In the study group, the levels of magnesium ions in plasma and erythrocytes were (1.29±0.06) mmol/L, (2.50±0.41) mmol/L, which were higher than those in the control group [(1.00±0.08) mmol/L, (1.87±0.39) mmol/L], there were significant differences (P<0.05); the calcium levels in plasma and erythrocytes of the study group were (2.71±0.09) mmol/L, (0.20±0.02) mmol/L, which were lower than those in the control group [(2.01±0.08) mmol/L, (0.29±0.03) mmol/L], there were significant differences (P<0.05); the total efficacy of the control group was 72.34% (34/47), which was lower than that of the study group [95.74% (45/47), P<0.05]. After treatment, the DBP in the study group was (73.20±5.23)mmHg (1 mmHg=0.133 kPa), which was lower than that in the control group [(90.02±6.28)mmHg, P<0.05]. Conclusions Magnesium sulfate combined with labetalol has good effect on pregnancy-induced hypertension syndrome. Key words: Pregnancy-induced hypertension syndrome; Labetalol; Magnesium sulfate; Plasma; Erythrocyte; Magnesium ion; Calcium ion