Effect of lipid changes during pregnancy on pregnancy induced hypertension syndrome

Abstract

Objective To investigate the correlation between changes of blood lipid in pregnant women and pregnancy induced hypertension syndrome(PIHS). Methods 103 cases with PIHS admitted from Sep.2010 to Sep. 2013 were the PIHS group, 100 cases of pregnant women without hypertension were the control group, and 100 cases of non-pregnant women were the normal group. The blood lipids of each group were detected. Results Total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), apolipoprotein b(ApoB)and lipoprotein-a[LP(a)]were significantly lower while high-density lipoprotein cholesterol(HDL-C)and apolipoprotein a1(ApoAI)were significantly higher in patients with mild PIHS than in patients with severe PIHS(P<0.05). TC, TG, LDL-C, ApoB, and LP(a)were significantly higher in PIHS group than in the normal group and the control group(P<0.05). HDL-C and ApoAI levels in PIHS group were significantly higher than those in the normal group, but lower than those in the control group(P< 0.05). In addition, normal blood lipid indexes were significantly higher in the control group than in the normal group(P< 0.05). Conclusion We should pay more attention to HDL-C and ApoAI in order to accomplish the goal of early discovery and early treatment of PIHS, improving maternal and neonatal outcomes. Key words: Pregnancy; Blood lipid; Pregnancy induced hypertension syndrome