Study on the correlation between the change of CD4 + T cell counts and the variance of total lymphocyte counts in HIV/AIDS patients

Abstract

Objective To analyze the correlation between the change of CD4 + T lymphocyte count (△CD4 +T) and the variance of peripheral blood total lymphocyte count(△TLC) and evaluate the effect of △TLC to substitute for CD4 +T count to predict HIV progression monitoring and the curative effect on clinical HAART treatment in HIV/AIDS patients. Methods Study the correlation between TLC and CD4 + T count and the correlation between △TLC and △CD4 + T count in 91 patients with HIV/AIDS. Study the date of ROC are-a, sensitivity, specificity, positive predictive value and negative predictive value for CD4 + T 200/μl, 350/μl to find the extent of TLC. Study the date of ROC area, sensitivity, specificity, positive predictive value and negative predictive value for △CD4 +T 50/μl、100/μl、200/μl、300/μl to find the extent of △TLC. Results The sig-nificant correlation (r value) between TLC and CD4 + T count was 0.716(P<0.01) in the patients. The re-markable dynamical correlations between△TLC and △CD4 + T were found comparing to that between TLC and CD4 + T count r value was 0.809(P<0.01). It was significant value in prediction CD4 + T count 200/μl and 350/μl with TLC cut-off 1300/μl and 1700/μl. Moreover,as more significant market to predict optimal △CD4 +T for 50/μl,100/μl,200/μl,for300/μl, △TLC were 170/μl,330/μl,630/μl,910/μl respectively. Conclu-sion There is straight line correlation between the change of CD4 + T cell counts and the variance of total lym-phocyte counts in HIV/AIDS patients. TLC especially △TLC for prediction of △CD4 + T can be available as a substitute method to estimate HIV disease progression and clinical HAART in some resource-constrained area of China. Key words: HIV; AIDS; CD4 Lymphocyte Count; Peripheral blood total lymphocyte count; Variance; correlation