Study on the correlation between familial aggregation and lung function damage and COPD Assessment Test scores in chronic obstructive pulmonary disease

Abstract

Objective To explore the association between familial aggregation and lung function damage and COPD Assessment Test (CAT) scores in patients with chronic obstructive pulmonary disease (COPD), and the correlation between lung function damage and CAT scores. Methods A prospective analysis was conducted on the patients with COPD in Shengjing Hospital of China Medical University from January 2016 to May 2017.The diagnostic criteria were in line with the 2017 global chronic obstructive pulmonary disease initiative.The gender, age, body mass index, smoking index and family history of the subjects were recorded.The case group was divided into a family history group and a no family history group.CAT score test and lung function test are performed on all subjects (including pulse forced oscillation, plethysmography, pulmonary ventilation, dispersion function detection). We analyzed the association between familial aggregation and lung function and CAT scores in the 2 groups, and the correlation between lung function and CAT scores. Results ①A total of 102 cases were included in the case group, among them, 59 cases were in the family history group (accounting for 57.84%), 43 cases were in the no family history group (accounting for 42.16%). There was no statistically significant difference between the two groups in gender, age, body mass index, smoking index and severity of airway limitation.②There was no statistically significant difference in the other indexes between the two groups except the percentage of the estimated value of carbon monoxide diffusing capacity (P<0.05) and the percentage of the estimated value of carbon monoxide diffusing capacity/alveolar volume (P<0.05). ③There was no statistically significant difference in CAT scores between the family history group and no family history group.④In no family history group, forced expiratory volume in the first second%pred (FEV1%pred) and forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) were not related to COPD assessment test scores.There was a weak and positive correlation between FEV1%pred, FEV1/FVC and CAT scores in family history group. Conclusions There was no relationship between the familial aggregation of COPD and the lung function and CAT scores.The correlation between lung function and CAT scores is weak. Key words: Chronic obstructive pulmonary disease; Familial aggregation; Lung function; COPD Assessment Test scores