Abstract
The physical characterization is an authentic proof for the metal and mineral drug formulations used in traditional system of medicine. Now a day quality assurance is a thrust area for the evaluation of traditionally used medicinal plants and herbal formulations. In this research work, author aims to elicit traditional and modern physical characterization of Siddha formulation Ayabirungaraja karpam(ABK). It was prepared as per Siddha reputed text classical method and subjected to physical characterization traditionally such as consistency, lightness, texture, particle size, colour, odour, tactile sensation, irreversible nature and modern parameters like pH value, Loss on drying, Total ash, acid insoluble ash, water soluble ash, Bulk density, Tapped density, Zeta size, Zeta potential and BET analysis for surface area. The results reveal as per traditional trait, ABK is non-adhesive freeness, fineness and lightness which enhance absorption and assimilation of particle in body without producing any irritation to the mucous membrane of gastrointestinal tract. Modern parameter indicate the presence of organic moieties as well as mineral, acidic medium which was not favour for microbial growth , cohesive, low porosity and compaction of drug powder was confirmed. Particle size matches well with colloidal size which attached to human intestine and thus provide large surface area, thereby increase absorption of macro, micronutrients and drug. Therefore, it is concluded the drug is user friendly for human oral administration.
Highlights
The quality control aspect has been covered by careful observation of skilful traditional medical practioner
The physical characterization is an authentic proof for the metal and mineral drug formulations used in traditional system of medicine
The results reveal as per traditional trait, ABK is non-adhesive freeness, fineness and lightness which enhance absorption and assimilation of particle in body without producing any irritation to the mucous membrane of gastrointestinal tract
Summary
The quality control aspect has been covered by careful observation of skilful traditional medical practioner. It eliminates toxicity of metals and make efficacious medicinal product for human beings and beneficial for the treatment of many diseases. This enhances the acceptability of traditional system of medicine all around the globe. (5) Various method of physicochemical analysis outcome revealed that the traditional formulations possess raw metals for their preparation lose their metallic characteristics and turn into mineral complex after processing. In their raw form, the metals like mercury, copper, iron, sulphur and lead etc. According to the ancient text of the traditional manufacturing process emphasize long duration of pharmaceutical processing whereby the ingredient are Nagalingam Varnakulendran et al, Study on physical properties of Ayabirungaraja Karpam grinding and heating cycles repeated several times with each cycle lasting 4-7 days and fired in furnaces at temperatures up to 6000 °C are believed to remove the toxicity and impart remarkable therapeutic value to the drug.(6)
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