Study on biosensor and its whole blood detection under the background of integrated traditional Chinese and western medicine

Abstract

The quantitative detection of biomolecules related to various diseases in blood is the basis of clinical diagnosis, prognosis monitoring, early disease prevention and controllability detection. However, so far, it is difficult to detect whole blood by clinical detection methods. Biosensors can be widely used in detection and analysis in the fields of medicine, environmental protection and industrial and agricultural production. Under the background of integrated traditional Chinese and western medicine, countries all over the world have invested heavily in technical research and product development of biosensors. The starting point of this paper is that it is difficult to realize direct detection of whole blood by fluorescence immunoassay technology at present. Based on the research of biosensors with solid-phase optical fiber and glass slide as biosensors, innovative research has been carried out in new probes and sensing methods of biomarkers. The research shows that combining the advantages of nano-probe with optical fiber evanescent wave biosensor can effectively reduce the influence of spectral scattering, light absorption and autofluorescence background in whole blood on detection signals, improve the accuracy of whole blood detection, realize the rapid detection of hemoglobin by biosensor, and meet the needs of clinical detection of hemoglobin concentration range.