STUDY OF URIC ACID LEVELS IN PATIENTS WITH HYPOTHYROIDISM AND ITS CORRELATION WITH SERUM THYROID STIMULATION HORMONE LEVELS

Abstract

Aim: we aimed to investigate whether there is a correlation between uric acid levels and TSH levels in the patients with hypothyroidism. This observational cross-sectional study was Material and method: conducted on patients attending OPD/ IPD of Hospitals afliated to Bangalore Medical College and Research Institute, Bangalore from November 2019 to May 2021. Data of all the patients satisfying the inclusion and exclusion criteria was collected. Data was analyzed by descriptive statistics. Pearson correlational analysis/Spearman's rank correlation was used to assess the correlation between Uric acid and TSH levels. A total of 90 cases were taken up Results: for the study. The mean age of the subjects was found to be 32±8 years, 82(91%) were females and only 8(9%) were males. The average height of the subjects was 158.67±9.31 cm. The average weight was 63.94±9.72 kg. The mean pulse rate of the subjects was 75.62±5.66, mean RR was 18.63±1.83, mean BP was 111±7/75±5. The average T3 was observed to be 1.59±0.96, average T4 was 3.83±3.73 and average TSH was 30.89±20.93. The mean serum uric acid of the subjects was 6.3±1.28 mg/dl, mean serum creatinine was 0.87±0.15 mg/dl and mean eGFR was 85.44±16.45, mean HB was 11.58±1.69, MCV was 79.81±6.76. Platate count was 2.92±1.35. The average Ferritin was found to be 185.21±359.03. The average LDH was 296.46±106.35, microcytic hypochromic anemia was present in 21(23%) subjects and normocytic normochromic anemia was present in 69(77%) subjects. Pearson correlation analysis showed that there was positive association between TSH and serum uric acid, among the subjects. However, the association was not found to be statistically signicant as p>0.05. Although not statistically Conclusion: signicant, a positive correlation was observed between the uric acid and thyroid stimulating hormone.