A study on comparison of serum creatinine, serum uric acid and serum zinc levels in hypothyroid and healthy controls-at a tertiary care hospital

Abstract

Background: Hypothyroidism is associated with many biochemical abnormalities including increased serum creatinine, uric acid, and decreased serum zinc levels. Many studies were done abroad regarding serum creatinine and uric acid levels in hypothyroid patients. We designed this study in our population for evaluation and comparison of serum creatinine, uric acid, and zinc levels in hypothyroid and healthy patients.Aim & Objective of the study: The main aim of the current study is to estimate and comparison of changes in serum creatinine, uric acid and zinc levels in hypothyroid patients and healthy controls.Materials and Methods: It is an observational prospective comparative study. This study was conducted at Mamatha Academy of Medical Sciences & Hospital, Bachupally, Hyderabad, Telangana from January 2019 to July 2019. There were 50 cases and 50 controls in the age groups from 18 to 65 years. Fresh samples were taken and required tests were performed following standard protocol. Creatinine and the uric acid level was estimated by semi auto analyzer and zinc level was estimated by atomic absorption spectrophotometerResults: In the present study, mean serum creatinine and uric acid levels in cases were 3.20± 0.65 and 9.20 ± 0.47 mg/dL respectively compared to 1.04 ± 0.22 and 5.15 ± 0.77 mg/dL in controls. Mean serum zinc levels in cases were 62.50±7.50 mg/dL compared to 95.45±11.05 mg/Dl in controls. The level of serum creatinine and uric acid were significantly high and serum zinc was significantly low (p-value