Abstract
The frequency of the occurrence of polymorphic variants rs2234693 (PvuII, T→C) of the ESR1 gene and rs731236 (TaqI, T→C) of the VDR gene was investigated in 95 patients with chronic obstructive pulmonary disease (COPD) and in 95 healthy people. A statistically significant increase (p = 0.006) in the frequency of the occurrence of the heterozygous TC genotype rs2234693 in the intron 1 of the ESR1 gene was found in the group of patients with COPD compared to the group of conditionally healthy people. The heterozygous TC genotype rs2234693 is associated with chronic obstructive pulmonary disease (OR = 5.21 CI = 1.43–19.0) was established. As for the rs731236 polymorphism of the VDR gene, there were no significant differences in the frequency of occurrence of one of the genotypes in patients with COPD and healthy people.
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