STUDY OF THE INFLUENCE OF BACTERIAL LYSATE ON OXIDATIVE STRESS INDICATORS IN EXPERIMENTAL PERIODONTIS IN RATS

Abstract

One of the stages of the pathophysiological study of the prooxidant-antioxidant state in terms of oxidative stress of the oral mucosa in rats with experimental periodontitis and pharmacological correction with bacterial lysate was carried out. Reproduction of periodontitis reliably led to a high degree of impairment of the lipid peroxidation (LPO) and antioxidant system (AOS), the red/ox-balance coefficient. It was proved that by the end of the 90-day period of observation of the course of periodontitis, the power of natural compensatory mechanisms acquired a state of decompensation, which was manifested by a high red/ox-balance ratio, inhibition of the functional activity of both non-enzymatic and enzymatic AOS links in the homogenate of gum tissue of control animal pathology: K (LPO/AOS) = 0.39, in intact animals = 1. The use of Respibron for 30 days contributed to the normalization of the antioxidant-prooxidant index, equal to 0.9 in this group and was statistically significantly higher than that in the Imudon group (0.64). The results obtained make it possible to continue studies of the course of experimental periodontitis from the point of view of establishing the mechanisms of development, protection, and restoration of tissues under conditions of pharmacological correction with the bacterial lysate Respibron®.