Abstract
The aim of the research: to experimentally study at the histological and morphological level the degree of the corrective effect of bacterial lysate of the disturbed non-specific defense of the body on the model of periodontitis based on the Central Research Laboratory of the National University of Pharmacy.
 Materials and methods: prospective study has been conducted on experimental periodontitis in 42 rats for 90 days. The animals were treated with «Respibron» and the reference drug «Imudon». Histological and morphometric studies were carried out according to standard methods. Micropreparations were viewed under a Granum DCM 310 digital video camera. All interventions and euthanasia of animals were carried out in compliance with the European principles.
 Results: by the end of 90 days of experimental periodontitis at the local level in the homogenate of animal gum tissue compensatory mechanisms are depleted and differed from the norm by 397 times. The dynamics of the studied morphometric and histological parameters of "Respibron" was similar to the "Imudon", but the magnitude of destruction was less pronounced and differed at the end of the experiment by 17.2 times in comparison with the intact control, and in the control group the results improved by 23.1 times.
 Conclusion: the obtained data from the study indicate a high decompensation of experimental periodontitis. It is characterized by the formation of periodontal pockets and inflammatory bone loss. The magnitude of destruction differed from the norm by 397 times. Applying of bacterial lysates led to the compensation of bacterial dysbiosis, restoration of the tissues of paradont. The therapeutic effect of "Respibron" can be assessed as more powerful in comparison with "Imudon" in terms of the studied morphometric and histological parameters: the magnitude of improvement "Respibron" was 3.72 times higher than the indicators of "Imudon". We should continue the study of experimental periodontitis as mechanisms of development, protection, and restoration of tissues under conditions of pharmacological correction by bacterial lysate "Respibron"
Highlights
The development of medicine has led to the understanding that almost any pathology is the cause or consequence of immunological disorders that contribute to the chronicity of the underlying disease and the occurrence of its complications [1]
It was found that inflammatory periodontal disease (IPD) are accompanied by immunological disorders of a general and local levels, therapy is based on the establishment of an accurate clinical and immunological diagnosis and the appointment of appropriate immunocorrective therapy [2, 3]
The animals were divided into 4 groups: 1st group - intact animals; 2nd group - rats with experimental periodontitis; 3rd - rats with experimental periodontitis, which were irrigated with an aqueous solution of «Respibron» at a dose of 10 mg / kg once a day; 4th group - rats with experimental periodontitis, which were irrigated with an aqueous solution of the reference drug
Summary
The development of medicine has led to the understanding that almost any pathology is the cause or consequence of immunological disorders that contribute to the chronicity of the underlying disease and the occurrence of its complications [1]. It was found that inflammatory periodontal disease (IPD) are accompanied by immunological disorders of a general (systemic) and local levels, therapy is based on the establishment of an accurate clinical and immunological diagnosis and the appointment of appropriate immunocorrective therapy [2, 3] This tactic is pathogenetically justified and contributes to the achievement of positive clinical results and prolongation of remission. Other similar preparations of the modern method of obtaining are distinguished by smaller antigenic molecules, with reduced ballast (antigen inactive), toxic parts of the microbial cell as "Respibron" This antigenic material is better recognized by the immune system and, forms a specific immune response, and the absence of toxic components makes it possible to avoid a general negative reaction of the body [7]. At this stage of our study, the task was to establish the dynamics of mor-
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