STUDY OF THE HUMAN BLOOD STATE AFTER THE EFFECT OF CORONAVIRUS INFECTION COVID-19

Abstract

The publication reveals the relevance of the research, which is due to the expediency of obtaining the maximum spectrum of measured values based on the flow cytometry method for further analysis of the impact of the COVID-19 coronavirus infection on the human body. The paper describes the directions of application of the flow cytometry method based on hematological markers in scientific research: the causes of immune system disorders were identified, the processes of thrombus formation and fibrinolysis were analyzed, and the causes of the pathogenesis of arterial hypertension were studied. The results of the specified method implementation meant for studying the state of blood after exposure to the human body by the coronavirus infection COVID-19 are presented in the following areas: the occurrence of alveolar inflammation, the appearance of immunological changes, the effect on lymphocyte cells, the appearance of chronic fatigue syndrome based on secondary immunodeficiency after the coronavirus disease. The advantages and disadvantages of using the flow cytometry method for determining hematological parameters after exposure to the human body by the coronavirus infection are indicated, and the feasibility of using the VS-6000 MINDRAY hematological analyzer is substantiated. Reference values have been defined, on the basis of which the automatically measured hematological indicators are compared, the most important in the analysis during the effect of the Covid-19 coronavirus infection on the body of an adult: the absolute content of leukocytes, lymphocytes, monocytes, granulocytes, etc. The importance of identifying biomarkers of inflammatory reactions for patients with various forms and courses of the disease, which is associated with morphological and functional changes in blood cells, starting from the early stages of exposure to the body of the coronavirus infection, has been indicated. It is substantiated that the analysis of the obtained hematological indicators for patients with the COVID-19 coronavirus infection involves considering many factors, based on which the final conclusion regarding changes in the blood state should be formulated. The advantages of using the flow cytometry method in studying the effect of coronavirus infection on the human body are shown.