Abstract
Abstract Background Breast cancer is a major health concern worldwide being the most frequently diagnosed cancer and a leading cause of cancer related death in females. It is a complex heterogeneous multifactorial disease where recently; genetic factors have emerged as major factors in the pathogenesis of the disease. Aim of the Work The aim of the present study is to investigate the association of TCF7L2 rs12255372 (G/T) gene polymorphism with breast cancer and the clinicopathological characteristics of the patients. Subjects and Methods It is a case control study conducted at Ain Shams University Hospitals, it includes 40 breast cancer female patients and 10 age matched healthy females. Results There was no statistically significant difference between the breast cancer patient group and the healthy female controls regarding TCF7L2 rs12255372 genotypes GG, GT and TT (p-value >0.05 respectively). Moreover, no statistically significant difference was observed between both groups as regards G and T allele frequencies (p-value > 0.05 respectively). Finally, no statistically significant difference association was recorded between the different genotypes of TCF7L2 gene and the clinicopathological characteristics of breast cancer patients (p-value > 0.05 respectively). Conclusion the present study demonstrated the absence of a significant association of TCF7L2 SNP rs12255372 (G/T) with breast cancer or with the clinicopathological characteristics of the tumor among the studied population.
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