Association of variants rs7903146 and rs290487 of TCF7L2 gene with diabetic nephropathy and co-morbidities (hypertension and dyslipidemia) in type 2 diabetes mellitus

Abstract

BackgroundDiabetes mellitus is a metabolic disorder which can affects the body's ability to produce or use of the hormone insulin leads to high blood sugar levels and it may serves as a host of complications. Emerging evidence suggests that common and rare genetic polymorphisms can influence the risk of developing diabetic complications. We attempt to evaluate the association of (rs7903146 and rs290487) variants of TCF7L2 gene with diabetic nephropathy and co-morbidities (hypertension and dyslipidemia) in T2DM. Material & methodsA total of 370 cases including 122 T2DM with Nephropathy, 119 T2DM with Hypertension, 129 T2DM with Dyslipidemia and 120 ethnicity matched healthy controls were included in this case-control study. TCF7L2 gene polymorphism was evaluated using polymerase chain reaction followed by restriction fragment length polymorphism analysis. ResultsSignificant difference in TCF7L2 (rs7903146) gene was observed when the genotype frequencies of group 1, 2 and 3 compare with control (p = 0.048, 0.005 and 0.004) whereas, no association of TCF7L2 (rs290487) gene was found with group 1, group 2 and group 3 (p = 0.808, 0.466 and 0.285). Significant difference in TCF7L2 (rs7903146) gene was observed when the genotype frequencies of group 1 and group 3 compare with group 2 (p < 0.001). ConclusionOur findings suggest that TCF7L2 (rs7903146) gene polymorphism might be involved in the pathogenesis of diabetic nephropathy and co-morbidities (hypertension and dyslipidemia) in T2DM.