Abstract
T. ivorensis is a plant used in traditional settings for the treatment of wounds and microbial infections. The lack of scientific study on the healing power of this plant is the basis of this study. The objective of this study is to evaluate the anti-inflammatory and healing potential of the hydroethanol extract of Terminalia ivorensis bark. The methodology consisted in the determination of the phenolic compounds present in the extract by the Folin-Ciocalteu reagent. The determination of antioxidant activity by the DPPH test was carried out using the method described by Molyneux. The anti-inflammatory effect was estimated from the measurement of the volume of the oedema of the paw of rats induced by carrageenan. In addition, a circular incision of 2 cm diameter was made in the dorsal region of each rat to evaluate the healing activity of the ethanolic extract against a reference ointment (L-Mesitran). The results showed that the phenolic compound content of the hydroethanolic extract is 62, 34±1.41 mg GSE per g powder. The IC50 values obtained were 9,67±1.12 µg/mL for vitamin C and 16,23±0.33 µg/mL. The inhibition of inflammation is 87% at the dose of 600mg/kg bw of T. ivorensis extract. This inhibition is greater than that of diclofenac, which resulted in 76,25% inhibition. At doses of 300 and 150mg/kg bw of the extract the inhibitions obtained were 76.43 and 72%. The reference ointment showed 50% healing at day 10 and 80% at the end of the experiment. For the ointments with concentrations of 15, 30, 60mg/ml the healing was 61,54%, 77,27% and 91,67% at the end of the 21 day study. For treatment with the extracts at the same concentrations, healing was 84,13%, 93,06% and 100% at concentrations 15, 30, 60mg/ml. The effect of the extract alone is greater than that of the ointment (extract + shea) at the same concentrations. The concentration of 60 mg/ml is the most active extract with or without shea butter.
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