Study of Serum Lipoproteins and their role in senile dementia

Abstract

Senile dementia is a neurodegeneration disease characterized by loss of memory, attention and cognitive functions. Lipoproteins are large lipid and protein complexes that play a major role in carrier of lipophilic and lipid molecule in plasma and central nervous system. The systemic hyperlipidemia may damage the Blood brain barrier via inflammatory and other mechanisms, with consequent leakage of serum lipoproteins. Inflammatory cytokines, and other amyloidogenic factors increases oxidative Stress and has important role in attention, cognition. In the present study we evaluated the levels of lipoproteins in Alzheimer's dementia patients, and observed significantly higher levels of lipoproteins in Alzheimer's dementia patients compared to healthy controls (P<0.001). The present study conducted on 50 healthy controls and 50 Alzheimer's dementia patients by using standard methods.