Comparative evaluation of enzymatic and non-enzymatic antioxidants in alzheimer dementia

Abstract

The senile dementia is a neurodegenerative disease characterized by loss of memory, attention and cognitive functions. The oxidants- antioxidant plays important role by several mechanism by reducing toxic Amyloid-β in neurons The Alzheimer's disease is due to Amyloid-β deposition in the brain and production of neurofibrillary tangles. Amyloid-β induces reactive oxygen species in brain of Alzheimer dementia patients. In the present study we evaluated the levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin B6 in Alzheimer dementia patients. It has been observed lower levels of Enzymatic, Non-Enzymatic Antioxidants and increased serum levels of malondialdehyde significantly in Alzheimer's dementia patients as compared to healthy controls (p < 0.001). Thus, altered oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia. Serum levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin B6 and Malondialdehyde (indicator of Lipid peroxidation) were measured using standard methods in 50 healthy controls and 50 Alzheimer's dementia patients.